Carbitrage podcast is all about cars, local Minnesota car culture, the superiority of manual transmissions, a general distaste for CUVs and welcoming the future of electric enthusiast vehicles
Long-form science podcast about how drugs, ideas & biotechnology impact our bodies & minds. Learn directly from the best scientists & thinkers alive today. New episodes every week. Learn more at: www.nickjikomes.com
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Mind & Matter


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Andrew Chadeayne: Chemistry of Magic Mushrooms, DMT Analogues, Entourage Effects in Cannabis & Fungi, Novel Psychedelic Medicines, Psychedelic Startups | #71
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Nick talks to chemist & patent attorney Dr. Andrew Chadeayne, who is the CEO of the psychedelic startup CaaMTech. They discussed: the chemistry of magic mushrooms, including compounds beyond psilocybin, found in many species of psilocybin-containing mushrooms; the so-called entourage effect, the idea that multiple compounds found in plants and fung…
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Martin Picard | Mitochondria, Aging, Cellular Energy, Metabolism, Gray Hair Reversal & Brain-Body Communication | #70
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Nick talks to Dr. Martin Picard, a biologist at Columbia University whose lab studies mitochondrial psychobiology, linking together molecular processes within mitochondria with human experience. They discussed; what mitochondria are and where they came from; their role in energy & metabolism; the mitochondrial genome; the importance of mitochondria…
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Leonard Guarente: Cellular Aging, Oxidative Stress, Antioxidants, Life Extension & Health Supplements | #69
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Nick talks to biologist Dr. Leonard Guarente about the biology of aging, life extension, health supplements, and related topics. Dr. Guarente is a Professor of Biology at MIT, where his lab has studied the molecular and cellular mechanisms of aging for many years. He is also the co-founder and Chief Scientist of Elysium Health, which uses the scien…
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Blanche Capel: Sex Determination, Sex Hormones & Chromosomes, Development & the Evolution of Sexual Reproduction | #68
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Nick talks to cell & developmental biologist Dr. Blanche Capel. They discussed the nature of sexual reproduction and sexual dimorphism, including when these these things evolved, the evolutionary reasons for sexual reproduction, and the amazing diversity of mechanisms that determine the development of sexual traits across the animal kingdom; the co…
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Rachel Yehuda: Stress, PTSD, Intergenerational Trauma, Epigenetics & Psychedelic Medicine | #67
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Nick talks to neuroscientist & clinical researcher Dr. Rachel Yehuda, who is a professor of psychiatry & neuroscience at the Icahn School of Medicine at Mount Sinai, in New York. They discuss the biology and neuroscience of stress, PTSD (post-traumatic stress disorder), why people can be sensitive or resilient to stress, epigenetics, intergeneratio…
On this episode of the Carbitrage Podcast, we talk about a Louisiana man rigging an explosive in his frequently broken in to vehicle, FCA bringing back heritage Alfa rebuilds in house, the Mercedes SL that was dead is.. back, VISA gets current with at the pump maximums upping to $125, Maverick ST?, Fuel economy fed standards come back after the pri…
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Robert Greene: The Psychology of Power & Social Status | #66
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Nick speaks to writer Robert Greene, who is the author of several books exploring different, and sometimes dark, aspects of human psychology. The discussion focuses on the subject of his first book, "The 48 Laws of Power." They discuss what power is and how it's used. Different psychological traits that people who successfully acquire power tend to…
On this episode of the Carbitrage Podcast, we talk best new MSRP buy for prospecting, Goodwood members club streaming live, WRX sales down 90% year over year, GR Corolla coming to the USA and what that means for us, ASIMO retiring, Holley's real life april fools joke, Japan's matter of fact safety holidaysCarbitrage Patreon: www.patreon.com/carbitr…
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Donald Hoffman: Consciousness, Perception, Evolution, Spacetime & the Nature of Reality | M&M #65
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Nick talks to cognitive scientist Dr. Donald Hoffman, who is professor emeritus of cognitive sciences at UC-Irvine and the author of many scientific papers and books, including "The Case Against Reality: Why Evolution Hid the Truth from Our Eyes.” They discussed a variety of topics related to consciousness, the nature of perception, and evolution, …
On this episode of the Carbitrage Podcast, we discuss Hagerty's Jason Cammisa and his piece on the Rivian, a DOHC head for the model A flat head four cylinder, the Lotus 132 and whether or not it's a wagon, Acura buries the new teg even more with NFTs, and recalls for headlights that are too bright on a 10 year old junk yard find.Carbitrage Patreon…
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Joe Baur: Aging, Metabolism, Calorie Restriction, NAD, Resveratrol, Rapamycin, Sirtuins, Longer Life | #64
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Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. These discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosupp…
On this episode of the Carbitrage Podcast, we tell you to buy the FC RX-7 before it's too late, Chigoland transit riders being forced to walk the L plank, a very nice Pierce Arrow *sing* found in a MN basement, Saudi GP nearly gets bombed, Nobe's adorable little retro pickup that won't come to the USA, or WILL IT?! FCA's new inline 6 gets a retro f…
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John Cryan: Microbiome-Gut-Brain Axis in Health & Disease | #63
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Nick talks to Dr. John Cryan, a Professor of Anatomy & Neuroscience at University College-Cork in Ireland whose lab studies the microbiota-gut-brain axis in health & disease. They touch on a range of topics related to how our gut microbiome affects the brain and body, including: how the microbiome affects aging and immunity; how it affects social b…
On this episode of the Carbitrage Podcast - we discuss turn key replica low volume legislation thats actually a really big deal, the VW ID.7 Buzz finally shown off in eu spec short wheelbase production trim, actual figures on the donual transmission, BMW buys alpina.. .wait? that didnt already happen 15 years ago? Veda Orr and her immense hot roddi…
On this episode of the Carbitrage Podcast, Ryan realizes he wont be getting his Brimach Taos after all, Hertz files more stolen car reports in a year than my home town population 10 fold, leading to some dicey reports and a huge counter suit. Gas prices are up and we figure out how far they have to go before it actually matters, GR Yaris is a bette…
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Gul Dolen: Social Cognition, Oxytocin, MDMA, Critical Periods, Metaplasticity, Autism, Psychedelics & Octopus Neurobiology | M&M #62
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Nick talks to Dr. Gul Dolen, a professor of neuroscience at Johns Hopkins University. Her lab studies the circuit and synaptic mechanisms of social cognition in health and disease. Nick and Dr. Dolen discussed her research on critical periods for social reward learning in rodents, the role of oxytocin in social behavior and learning, and how MDMA (…
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Martin Kulldorff: Public Health, Epidemiology, Pandemics, Immunity, SARS-CoV-2 & COVID-19 Public Policy | #61
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Martin Kulldorff, PhD is an epidemiologist & biostatistician who has been studying infectious diseases for over two decades. He was a professor at Harvard Medical School for many years, a member of the FDA’s Drug Safety & Risk Management Advisory Committee, and a former consultant for the Centers for Disease Control. In 2020, Dr. Kulldorff co-autho…
On this episode of the Carbitrage Podcast, federal infrastructure crumbles on queue to discuss crumbling federal infrastructure, Black History month is here and we talk about the C.R. Patterson and sons company. Dr. Wags the F31 and parts engineered to fail. English folk take to the streets to poke fun at Boris Johnson, and you might be able to buy…
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Bernardo Kastrup: Consciousness, Dissociation, Metacognition, Idealism, Materialism, Philosophy, Psychedelics, Death & Mind | #60
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Nick talks to computer scientist and philosopher Bernardo Kastrup about various topics related to consciousness and the nature of reality. They discuss: psychological dissociation; the scientific study of 'neural correlates of consciousness'; the nature of perception and the influence of language on the mind; why the 'Hard Problem' of consciousness…
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Marsha Rosner: CBD (Cannabidiol), Antiviral Drugs, SARS-CoV-2 & Cancer Biology | #59
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Nick Jikomes talks to cancer biologist Dr. Marsha Rosner, who is a Professor of Cancer Research at the University of Chicago. Her lab focuses largely on understanding the biochemical signaling mechanisms that lead to the generation of tumor cells, as well as how and why cancer cells metastasize, which is when they travel from one part of the body t…
On this episode of the Carbitrage Podcast, we discuss McKinley Thompson, JR - the father of the ford bronco as our black history month spotlight this week. On the heels of Mazda and Mercedes, Stellantis is joining BMW in a mass market straight 6 engine, Toyota's Camry has been in NASCAR for longer than a Dodge product. Rivian vs Tundra in highway r…
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Kevin McKernan: Genomics, PCR, COVID Testing, mRNA Vaccines, Blockchain Technology, Psilocybin Mushroom & Cannabis Genomes | #58
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Kevin McKernan is a renowned leader in DNA sequencing technology. He led a research team part of the original Human Genome Project and is the founder and Chief Science Officer of Medicinal Genomics, a life sciences company that distributes genetics-based platforms for quality and safety testing of legal cannabis. Nick and Kevin discussed the Cannab…
On this episode of the carbitrage podcast, we discuss Richard Spikes on Black History month for inventing the pre selector gearbox, the 3000GT breaks 100,000 at auction, $5B bipartisain bill pushes much needed funding in to federal EV charging infrastructure, Dihatusi wins ths tokyo auto salon again this year, but in a diffferent way, the upcoming …
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Alexandra Elbakyan: Sci-Hub, Open Data, Freedom of Information & the Democratization of Science | #57
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Nick talks to Alexandra Elbakyan, the founder of Sci-hub, a shadow library website that provides free access to millions of research papers and books, without regard to copyright, by bypassing publishers' paywalls in various ways. Sci-hub is used by millions of people around the world each month, granting them free and easy access to scientific res…
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Suzanne Devkota: Gut Microbiome, Diet, Inflammation, Probiotics, Skin Care, Acne, Obesity & IBS | M&M #56
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Nick talks to Dr. Suzanne Devkota, a microbiologist whose lab studies the gut microbiome in health and disease. They discuss a variety of topics related to the gut microbiome: how it is influenced by diet; how antibiotics and probiotics affect it; different disease states and metabolic disorders, such as IBS and obesity; how gut microbes can affect…
On this episode of the Carbitrage Podcast, we look at picking out a car for a new st bernard pup dad, the GMA T.33 and its overwhelming manual take rate, Tommy Pastrami (travis pastrana)'s new subaru wagon, Santa Fe gauge clusters going in to australia mode, the hammer price on the Hirohata merc, and Tesla's appaling quality issues don't make it pa…
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Amy Reichelt: Diet, Eating Habits, Obesity, Food Addiction, Psychedelics, Nutrition & the Brain | #55
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Nick talks to Dr. Amy Reichelt, a neuroscientist and expert on the effects of diet and nutrition on the brain. They discussed how the brain is wired to help us learn about food, how what we eat influences the function of circuits within the brain, how certain diets can actually cause damage to the brain and negatively impact learning, obesity, and …
On this episode of the Carbitrage Podcast, we look at an after-market company that makes a real steering wheel for the Model S and X to get rid of that stupid yoke, Volvo 245s about to become the next unaffordable thing, Stallantis brought a slew of new 500es to CES, does that mean we might have a new Fiat 500 states-bound? Planters taking a page o…
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Paul Barrett: Dinosaurs, Paleontology, Mass Extinctions, Evolution, Past & Future of Life on Earth | #54
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Nick talks to Dr. Paul Barrett, a paleontologist at the Natural History Museum in London, UK. Paul has spent nearly 30 years as a paleontologist studying the evolution and biology of dinosaurs and other extinct reptiles. He has authored over 200 scientific papers, and his speciality is in non-avian dinosaurs. Nick talked to Paul about all things di…
On this episode of the Carbitrage Podcast, we conclude the obvious in that no one likes the Toyota CH-R, Toyota saving that story with news that the MKV Supra is enroute to the USA with a 6-speed manual on the B48 and B58 engines, and GR-MN version is coming with the S58 as well. Front wheel drive Celicas are under rated cars, Corolla hatch XSE tri…
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Reggie Gaudino: Phytochemistry, Biochemistry, Genomics & Breeding of Commercial Cannabis | #53
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Nick talks to Dr. Reggie Gaudino, a molecular geneticist and expert in the phytochemistry, biochemistry, genomics, and breeding of commercial Cannabis. He is the former Chief Science Officer of Steep Hill, one of the first cannabis testing labs in the US, and is currently VP of Research & Development at Frontrange Biosciences. Nick & Reggie discuss…
On this episode of the Carbitrage Podcast, we talk CES and its car reveals and tech, Janas $3000 nanny challenge, the Buzz EV ID.7 getting an official build start date, i9 pileup started by idiots with bad tires, tesla breaking their UI and freezing owners to death, Hirohatat Merc custom for sale at MecumCarbitrage Patreon: www.patreon.com/carbitra…
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David Roberson: Painkillers, Opioids, Heroin, Fentanyl, Oxycodone, NSAIDs, & Neuroscience of Pain | #52
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Nick Jikomes talks to Dr. David Roberson, a neuroscientist and co-founder of three ongoing biotech companies: Nocion Therapeutics, Blue Therapeutics, and Blackbox Bio. David is an expert in the neuroscience of pain and the conversation focuses mainly on pain: how does our brain sense and perceive pain? Why does pain sometimes become chronic, and la…
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Alexandros Marinos: Systems Thinking, Organizational Structures, Building Startups, Remote Work & Control vs. Enablement | #51
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Nick talks to Alexandros Marinos, PhD, founder & CEO of the edge computing technology startup, Balena. They discuss the internal organization of complex human systems. Alex talked about how he thinks about the organizational structure of his own company and how organizational structures impact group dynamics, growth, conflicts of interest, and inno…
On this episode of the Carbitrage Podcast, we talk about the NIO model 3 fighter we probably won't see in the states, Albert Biermann, father of moden M and Hyundai's N line, retires, Citroen ami gets a buggy guise, China brings a funky electric KEI convertible to market with a soft top and neon colors, Nissan's stanza NewBird looks like I EV swapp…
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Chris Weikart: Medical Glass, Materials Science & the COVID Vaccine Supply Chain | #50 | Supported by SiO2
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Nick Jikomes talks to materials scientist Dr. Chris Weikart, who is currently chief scientist at SiO2, an advanced materials science company that combines chemistry and engineering to create containers and surfaces for use by biotechnology, genomics, diagnostics, and consumer products companies. They discuss how SiO2 created a new kind of vaccine v…
On this episode of the Carbitrage Podcast, we discuss Polestar's third vehicle offering, called 3. Cool cars you want your friend to buy instead of yourself due to horrible reliability, living with wintery climates and how cars change, new DOT signs coming soon, Hyundai ionic 5 starts to roll off the line, Nissan restores a power ranger daily drive…
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Jonathan Schaefer: Does Adolescent Marijuana (Cannabis) Use Cause Psychosis? | #49
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Nick Jikomes talks to Dr. Jonathan Schaefer about the link between adolescent cannabis (marijuana) use and psychosis. Jonathan has a PhD in clinical psychology and he is currently a research psychologist at the University of Minnesota Institute of Child Development. His research focuses largely on the relationship between people’s environments that…
On this episode of the Carbitrage Podcast, we discuss Subaru and its design incest, ferrari actually making a terrible CUV, Lamborghini Trattori, the Bremach Taos in actual trim coming to US with manual transmission, one of the EB 110's ugly 4 door stepbrothers comes up on the auction block with some pretty cool specs, Lancia tames down its Ypsilon…
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Sam Wang: Autism, the Cerebellum, Learning, Brain Development, Gerrymandering & Using Data Science to Repair Democracy | #48
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Nick Jikomes talks to Sam Wang, PhD professor of neuroscience at Princeton University. Dr. Wong’s lab investigates how brains learn from sensory experience, in adulthood and development, with relevance for autism. A lot of their work focuses on a part of the brain called the cerebellum. They talk about the cerebellum and what we’re learning about i…
On this episode of the Carbitrage Podcast, we recap JCCS, SEMA 2021, Alaska's EV bus that works just fine in the cold, Hertz backlogging tesla deliveries, VW Buzz spotted in near finalized looking sheet metal, Tri-5 meets electric with the Songsan Monterey, BMW already planning to replace the existing X5 chassis after just 3 years due to ugliness, …
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Nathan Price: Metabolism, Blood Sugar, Diabetes, Microbiome, Diet, Aging, Digital Phenotyping & Personalized Medicine | #47
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Nick Jikomes talks to Dr. Nathan Price, who has a PhD is in bioengineering and has been faculty at the University of Washington and the Institute of Systems Biology. He was also CEO of a health intelligence startup called Onegevity, which recently merged with Thorne HealthTech, which he is Chief Science Officer of. Nathan and Nick discussed various…
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David Olson: Psychedelics, Psychoplastogens, Microdosing, Brain Chemistry, Mental Health, Creating Novel Drugs | #46
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Nick Jikomes talks to medicinal chemist Dr. David Olson whose lab at the University of California-Davis studies a class of compounds called ‘psychoplastogens,’ which are small molecules capable of promoting neural plasticity. His lab is on the cutting edge when it comes to understanding the mechanisms by which psychedelics and other psychoactive dr…
ON this episode of the Carbitrage Podcast, we're back! slightly new home but recording once again! Acura butchered the Integra concept in to reality, consumer reports finally gets something right about Tesla, Hyundai does another modern classic restoration to join the Pony, Chinese market design pressure gets something right with Buick, the IH scou…
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Alina Chan: The Mystery of SARS-CoV-2 & Origins of COVID-19 | #45
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Nick Jikomes talks to genetic engineer Dr. Alina Chan about the origins of the SARS-CoV-2 virus responsible for the COVID-19 pandemic. They discuss Alina's new book, "Viral: The Search For the Origin of COVID-19," which she co-wrote with Matt Ridley. The book thoroughly documents the events & people relevant to COVID's origins. They discuss everyth…
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Anil Seth: Consciousness, Perception, Hallucinations, Selfhood, Neuroscience, Psychedelics & "Being You" | #44
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Nick talks with Dr. Anil Seth, a neuroscientist and professor of cognitive & computational neuroscience at the University of Sussex. The conversation is all about the neuroscience of consciousness, which is the subject of his Dr. Seth's book, “Being You: A New Science of Consciousness.“ They touch on everything from what consciousness actually is, …
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Erik Hoel: Sleep, Dreaming, Deep Neural Networks, Machine Learning & Artificial Intelligence, Overfitted Brain Hypothesis, Evolution of Fiction & Art | #43
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Nick talks to neuroscientist and writer Dr. Erik Hoel. Erik is a professor of biology at Tufts University. He received his PhD in neuroscience from the University of Wisconsin, where he studied under the sleep and consciousness researcher, Giulio Tononi. He did postdoctoral work at Columbia University, where he used information theory and other ana…
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Steve Laviolette: THC, CBD, Omega-3 Fatty Acids, L-Theanine, Opioids, Pregnancy, Brain Development, Addiction, Anxiety & Schizophrenia | #42
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Nick Jikomes talks to Dr. Steven Laviolette, a neuroscientist at the University of Western Ontario. They discuss how different types of drugs impact emotion, cognition, brain development and the development of psychiatric conditions (e.g. addition, schizophrenia); drug interactions (THC + CBD, THC + L-Theanine, CBD + Omega-3 Fatty Acids), how drugs…
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Saoirse O'Sullivan: Cannabinoids, CBD, THCV, CBG, Inflammation, Brain Injury, Diabetes, Gut Health & Academia vs. Industry | #41
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Nick Jikomes talks to Saoirse O'Sullivan, PhD, a physiologist specializing in the physiological effects of cannabinoids. Dr. O'Sullivan ran a lab at the University of Nottingham for many years before becoming a consultant and Vice President of Translational Research at Artello Biosciences. They discuss some of the physiological effects of cannabino…
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Christian Luscher: Drug Addiction, Cocaine, Nicotine, Caffeine, Amphetamines, Opioids, THC & Neuroscience | #40
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Christian Luscher, MD, PhD is a neuroscientist and neurologist who runs a research lab at the University of Geneva in Switzerland. Dr. Lusher's lab studies the mechanisms that underlie drug reinforcement and addiction in the brain and he is an expert in the neuroscience of drug addiction. Christian talks to Nick Jikomes about: what is addiction is …