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Nick talks to chemist & patent attorney Dr. Andrew Chadeayne, who is the CEO of the psychedelic startup CaaMTech. They discussed: the chemistry of magic mushrooms, including compounds beyond psilocybin, found in many species of psilocybin-containing mushrooms; the so-called entourage effect, the idea that multiple compounds found in plants and fung…
 
Nick talks to Dr. Martin Picard, a biologist at Columbia University whose lab studies mitochondrial psychobiology, linking together molecular processes within mitochondria with human experience. They discussed; what mitochondria are and where they came from; their role in energy & metabolism; the mitochondrial genome; the importance of mitochondria…
 
Nick talks to biologist Dr. Leonard Guarente about the biology of aging, life extension, health supplements, and related topics. Dr. Guarente is a Professor of Biology at MIT, where his lab has studied the molecular and cellular mechanisms of aging for many years. He is also the co-founder and Chief Scientist of Elysium Health, which uses the scien…
 
Nick talks to cell & developmental biologist Dr. Blanche Capel. They discussed the nature of sexual reproduction and sexual dimorphism, including when these these things evolved, the evolutionary reasons for sexual reproduction, and the amazing diversity of mechanisms that determine the development of sexual traits across the animal kingdom; the co…
 
Nick talks to neuroscientist & clinical researcher Dr. Rachel Yehuda, who is a professor of psychiatry & neuroscience at the Icahn School of Medicine at Mount Sinai, in New York. They discuss the biology and neuroscience of stress, PTSD (post-traumatic stress disorder), why people can be sensitive or resilient to stress, epigenetics, intergeneratio…
 
Nick speaks to writer Robert Greene, who is the author of several books exploring different, and sometimes dark, aspects of human psychology. The discussion focuses on the subject of his first book, "The 48 Laws of Power." They discuss what power is and how it's used. Different psychological traits that people who successfully acquire power tend to…
 
Nick talks to cognitive scientist Dr. Donald Hoffman, who is professor emeritus of cognitive sciences at UC-Irvine and the author of many scientific papers and books, including "The Case Against Reality: Why Evolution Hid the Truth from Our Eyes.” They discussed a variety of topics related to consciousness, the nature of perception, and evolution, …
 
Nick talks to biochemist Joe Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. These discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosupp…
 
Nick talks to Dr. John Cryan, a Professor of Anatomy & Neuroscience at University College-Cork in Ireland whose lab studies the microbiota-gut-brain axis in health & disease. They touch on a range of topics related to how our gut microbiome affects the brain and body, including: how the microbiome affects aging and immunity; how it affects social b…
 
Nick talks to Dr. Gul Dolen, a professor of neuroscience at Johns Hopkins University. Her lab studies the circuit and synaptic mechanisms of social cognition in health and disease. Nick and Dr. Dolen discussed her research on critical periods for social reward learning in rodents, the role of oxytocin in social behavior and learning, and how MDMA (…
 
Martin Kulldorff, PhD is an epidemiologist & biostatistician who has been studying infectious diseases for over two decades. He was a professor at Harvard Medical School for many years, a member of the FDA’s Drug Safety & Risk Management Advisory Committee, and a former consultant for the Centers for Disease Control. In 2020, Dr. Kulldorff co-autho…
 
Nick talks to computer scientist and philosopher Bernardo Kastrup about various topics related to consciousness and the nature of reality. They discuss: psychological dissociation; the scientific study of 'neural correlates of consciousness'; the nature of perception and the influence of language on the mind; why the 'Hard Problem' of consciousness…
 
Nick Jikomes talks to cancer biologist Dr. Marsha Rosner, who is a Professor of Cancer Research at the University of Chicago. Her lab focuses largely on understanding the biochemical signaling mechanisms that lead to the generation of tumor cells, as well as how and why cancer cells metastasize, which is when they travel from one part of the body t…
 
Kevin McKernan is a renowned leader in DNA sequencing technology. He led a research team part of the original Human Genome Project and is the founder and Chief Science Officer of Medicinal Genomics, a life sciences company that distributes genetics-based platforms for quality and safety testing of legal cannabis. Nick and Kevin discussed the Cannab…
 
Nick talks to Alexandra Elbakyan, the founder of Sci-hub, a shadow library website that provides free access to millions of research papers and books, without regard to copyright, by bypassing publishers' paywalls in various ways. Sci-hub is used by millions of people around the world each month, granting them free and easy access to scientific res…
 
Nick talks to Dr. Suzanne Devkota, a microbiologist whose lab studies the gut microbiome in health and disease. They discuss a variety of topics related to the gut microbiome: how it is influenced by diet; how antibiotics and probiotics affect it; different disease states and metabolic disorders, such as IBS and obesity; how gut microbes can affect…
 
Nick talks to Dr. Amy Reichelt, a neuroscientist and expert on the effects of diet and nutrition on the brain. They discussed how the brain is wired to help us learn about food, how what we eat influences the function of circuits within the brain, how certain diets can actually cause damage to the brain and negatively impact learning, obesity, and …
 
Nick talks to Dr. Paul Barrett, a paleontologist at the Natural History Museum in London, UK. Paul has spent nearly 30 years as a paleontologist studying the evolution and biology of dinosaurs and other extinct reptiles. He has authored over 200 scientific papers, and his speciality is in non-avian dinosaurs. Nick talked to Paul about all things di…
 
Nick talks to Dr. Reggie Gaudino, a molecular geneticist and expert in the phytochemistry, biochemistry, genomics, and breeding of commercial Cannabis. He is the former Chief Science Officer of Steep Hill, one of the first cannabis testing labs in the US, and is currently VP of Research & Development at Frontrange Biosciences. Nick & Reggie discuss…
 
Nick Jikomes talks to Dr. David Roberson, a neuroscientist and co-founder of three ongoing biotech companies: Nocion Therapeutics, Blue Therapeutics, and Blackbox Bio. David is an expert in the neuroscience of pain and the conversation focuses mainly on pain: how does our brain sense and perceive pain? Why does pain sometimes become chronic, and la…
 
Nick talks to Alexandros Marinos, PhD, founder & CEO of the edge computing technology startup, Balena. They discuss the internal organization of complex human systems. Alex talked about how he thinks about the organizational structure of his own company and how organizational structures impact group dynamics, growth, conflicts of interest, and inno…
 
Nick Jikomes talks to materials scientist Dr. Chris Weikart, who is currently chief scientist at SiO2, an advanced materials science company that combines chemistry and engineering to create containers and surfaces for use by biotechnology, genomics, diagnostics, and consumer products companies. They discuss how SiO2 created a new kind of vaccine v…
 
Nick Jikomes talks to Dr. Jonathan Schaefer about the link between adolescent cannabis (marijuana) use and psychosis. Jonathan has a PhD in clinical psychology and he is currently a research psychologist at the University of Minnesota Institute of Child Development. His research focuses largely on the relationship between people’s environments that…
 
Nick Jikomes talks to Sam Wang, PhD professor of neuroscience at Princeton University. Dr. Wong’s lab investigates how brains learn from sensory experience, in adulthood and development, with relevance for autism. A lot of their work focuses on a part of the brain called the cerebellum. They talk about the cerebellum and what we’re learning about i…
 
Nick Jikomes talks to Dr. Nathan Price, who has a PhD is in bioengineering and has been faculty at the University of Washington and the Institute of Systems Biology. He was also CEO of a health intelligence startup called Onegevity, which recently merged with Thorne HealthTech, which he is Chief Science Officer of. Nathan and Nick discussed various…
 
Nick Jikomes talks to medicinal chemist Dr. David Olson whose lab at the University of California-Davis studies a class of compounds called ‘psychoplastogens,’ which are small molecules capable of promoting neural plasticity. His lab is on the cutting edge when it comes to understanding the mechanisms by which psychedelics and other psychoactive dr…
 
Nick Jikomes talks to genetic engineer Dr. Alina Chan about the origins of the SARS-CoV-2 virus responsible for the COVID-19 pandemic. They discuss Alina's new book, "Viral: The Search For the Origin of COVID-19," which she co-wrote with Matt Ridley. The book thoroughly documents the events & people relevant to COVID's origins. They discuss everyth…
 
Nick talks with Dr. Anil Seth, a neuroscientist and professor of cognitive & computational neuroscience at the University of Sussex. The conversation is all about the neuroscience of consciousness, which is the subject of his Dr. Seth's book, “Being You: A New Science of Consciousness.“ They touch on everything from what consciousness actually is, …
 
Nick talks to neuroscientist and writer Dr. Erik Hoel. Erik is a professor of biology at Tufts University. He received his PhD in neuroscience from the University of Wisconsin, where he studied under the sleep and consciousness researcher, Giulio Tononi. He did postdoctoral work at Columbia University, where he used information theory and other ana…
 
Nick Jikomes talks to Dr. Steven Laviolette, a neuroscientist at the University of Western Ontario. They discuss how different types of drugs impact emotion, cognition, brain development and the development of psychiatric conditions (e.g. addition, schizophrenia); drug interactions (THC + CBD, THC + L-Theanine, CBD + Omega-3 Fatty Acids), how drugs…
 
Nick Jikomes talks to Saoirse O'Sullivan, PhD, a physiologist specializing in the physiological effects of cannabinoids. Dr. O'Sullivan ran a lab at the University of Nottingham for many years before becoming a consultant and Vice President of Translational Research at Artello Biosciences. They discuss some of the physiological effects of cannabino…
 
Christian Luscher, MD, PhD is a neuroscientist and neurologist who runs a research lab at the University of Geneva in Switzerland. Dr. Lusher's lab studies the mechanisms that underlie drug reinforcement and addiction in the brain and he is an expert in the neuroscience of drug addiction. Christian talks to Nick Jikomes about: what is addiction is …
 
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