show episodes
 
The World Parkinson Coalition is a nonprofit organization dedicated to providing an international forum on Parkinson's disease. Learn more at wpc2022.org
 
Nobel prize-winners and bestselling authors from around the world rubbed shoulders with the literary stars of tomorrow at the 2011 Edinburgh International Book Festival in over 800 events which included enlightening Parkinson-style chats, lively debates and readings. You can listen to extracts from some of the events in our series of free podcasts, recorded live at the festival.
 
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show series
 
In this episode, Ayesha discussed the FDA approval of Mycovia Pharmaceuticals’ Vivjoa (oteseconazole) as the first approved treatment for recurrent vulvovaginal candidiasis (RVVC) or chronic yeast infection. The drug is indicated for women who permanently lack reproductive potential or are postmenopausal. The editorial team discussed the significan…
 
In this episode, Ayesha talked about World Immunization Week, which is celebrated during the last week of April every year. The theme of this year’s World Immunization Week is “Long Life For All,” which aims to communicate the importance of vaccines for a healthy and fulfilling life by protecting yourself and your loved ones against deadly diseases…
 
In this episode, Ayesha discussed BioNTech’s new collaboration with Matinas BioPharma to explore the company’s lipid nanocrystal (LNC) delivery technology for mRNA vaccines. LNC structures are more stable than the lipid nanoparticle technology used in the current COVID-19 mRNA vaccines. Learn about how BioNTech hopes to leverage Matinas’ LNC platfo…
 
In this episode, Xtalks is marking World Parkinson’s Day (April 11) and Parkinson’s Awareness Month, which are observed every year to help raise awareness about the disease and the individuals living with it. To learn more about new Parkinson’s disease research, Ayesha discussed a new study by researchers at Rush University Medical Center that show…
 
In this episode, Ayesha shared insights she obtained from experts at NIH’s National Heart, Lung and Blood Institute (NHLBI) about clinical trial diversity. The panel of experts outlined some of the challenges in recruiting participants from minority and disadvantaged socioeconomic backgrounds, and talked about an NHLBI initiative based on community…
 
In this episode, Ayesha discussed Pfizer’s voluntary recall of several lots of its blood pressure medication Accuretic and two generic versions of it due to higher than acceptable levels of a carcinogenic nitrosamine compound. The recall affects lots produced between November 2019 and March 2022. The editorial team discussed the increasing frequenc…
 
In this episode, Ayesha shed light on National Colorectal Cancer Awareness Month by talking about a new colon cancer screening campaign from Exact Sciences that features a TV ad with Katie Couric. Couric, who is a long-time advocate of colon cancer screening after her husband passed away from colon cancer over 20 years ago, continues her mission to…
 
In this episode, Ayesha talks about new revelations about how Johnson & Johnson funded studies in the early 1970s that involved injecting prisoners in a Pennsylvania jail, most of whom were Black, with asbestos. The company wanted to compare the effects of asbestos versus talc, one of the main ingredients in Johnson & Johnson’s baby powder, on the …
 
In this episode, Ayesha spoke about some of the top women leaders in life science industries in celebration of International Women’s Day. While women remain underrepresented in STEM and life science industries, there are more women in leadership positions at pharmaceutical, biotechnology and medical device companies than ever before. Studies also s…
 
In this episode, the editorial team discussed Rare Disease Day which is celebrated every year on February 28 (or February 29 in leap years). This year’s theme was “Share Your Colours,” where individuals with rare diseases were encouraged to share their experiences and aspirations to help raise awareness. The campaign from rarediseaseday.org include…
 
In this episode, Ayesha discussed BioNTech’s new modular mRNA factories, called the BioNTainer, that are destined for Africa to help boost COVID-19 vaccine supplies on the continent. The modular production units are housed in containers that come equipped with raw starting materials and state-of-the-art technology for producing mRNA-based vaccines …
 
In this episode, Ayesha discussed the NHS’s recommendation of Libmeldy, a gene therapy for the treatment of the rare disease MLD, which is officially the world’s most expensive drug with a list price of almost $4 million USD. The drug was developed by Orchard Therapeutics and the NHS was able to negotiate a greater discount on it with the company s…
 
In this episode, Ayesha talked about a new at-home blood pressure monitor developed by Inbody that can track blood pressure in real time. The device uses the automated oscillometric method, commonly used in clinical settings now, to generate mean arterial pressure and calculate systolic and diastolic blood pressure from it using an algorithm. The d…
 
In this episode, Ayesha talked about the recent FDA approval for Immunocore’s Kimmtrak for the treatment of a rare type of eye cancer called uveal melanoma. Not only has the treatment become Immunocore’s first commercial product, but it has also become the first approved treatment for uveal melanoma and the first ever approved T cell receptor (TCR)…
 
In this episode, Ayesha discussed Gilead Science’s lawsuit against a network of distributors selling counterfeits of the company’s best-selling HIV drugs Biktarvy and Descovy. The drugs were being sold in pharmacies across several states. Gilead said it had been working with the US Marshals and local law enforcement to conduct seizures of over 85,0…
 
In this episode, Ayesha talks about a new study from UCSF that shows how physical activity can maintain brain health in older individuals. The research shows that exercise increases levels of synaptic proteins in the brain involved in maintaining and strengthening neuronal connections. The researchers also found these proteins could be protective e…
 
In this episode, Ayesha discussed a new blood test developed by researchers at the University of Oxford that can detect cancers and even if they’ve metastasized. The test is based on measuring metabolites produced by tumor cells in blood samples using nuclear magnetic resonance (NMR) spectroscopy. The researchers found that the test could identify …
 
In the first episode of 2022, Ayesha provided updates on Omicron and COVID-19 vaccine boosters. The FDA expanded authorization of booster doses of Pfizer’s COVID-19 vaccine to youth between 12 and 15 years of age, a third dose for immunocompromised children between five and 11 years old and a shorter wait time to get a booster for individuals 12 an…
 
In this episode, which is the last episode for the year (the team will be back in January!), Ayesha discusses the FDA approval of Biohaven’s intranasal spray Zavegepant indicated for the acute treatment of migraines in adults. The drug is similar to the company oral dose tablet (ODT) Nurtec but is the first CGRP receptor antagonist in a nasal spray…
 
In this episode, Ayesha discussed statements from Moderna and Pfizer regarding Omicron and the need for new variant-specific boosters. Moderna’s CEO sparked concerns when he said the current vaccines likely won’t be effective against Omicron, while Pfizer’s CEO said vaccines for COVID-19 will likely be needed for many years. The editorial team disc…
 
In this episode, Ayesha discussed Omicron, the latest SARS-CoV-2 variant of concern. The editorial team talked about the emergence of variants amid low vaccine uptake in some parts of the world owing to vaccine inequities and vaccine hesitancy. Omicron’s transmissibility, severity and the effectiveness of the current vaccines against it remain unkn…
 
In this episode, Ayesha discussed the first FDA-approved virtual reality treatment for chronic lower back pain. The virtual reality system is called EaseVRx and is developed by virtual reality medtech company AppliedVR. The non-invasive treatment system is self-administered and is designed for at-home use. It consists of a virtual reality headset, …
 
In this episode, the editorial team had the opportunity to speak with Dr. Brett Wingeier, CEO of neuromodulation MedTech company Magnus Medical about the company’s Magnus System for the treatment of major depressive disorder (MDD). The neurostimulation device received breakthrough device designation from the US Food and Drug Administration (FDA) la…
 
In this episode, the editorial team discussed Pfizer’s new oral antiviral pill for the treatment of COVID-19. Pfizer released data from an interim analysis of a Phase III trial evaluating the drug, which shows that it can reduce the risk of hospitalizations by almost 90 percent. It also prevented COVID-19 related deaths in the study. The results we…
 
In this episode, Ayesha discusses the FDA’s authorization of Pfizer/BioNTech’s COVID-19 vaccine for children between five and 11 years of age. The authorization was based on trial data that showed the vaccine was safe, well-tolerated and induced robust immune responses among children in this age group; side effects were generally mild to moderate. …
 
In this episode, the editorial team discusses the FDA approval of Cyltezo as the first interchangeable biosimilar for AbbVie’s Humira. The approval lends to the growing Humira biosimilars market, which will take off in 2023 with Boehringer Ingelheim’s Cyltezo and biosimilars from Amgen, Merck and Alvotech. AbbVie has been facing a lot of heat over …
 
In this episode, the editorial team talks about Moderna’s unwillingness to share its COVID-19 vaccine formula with other countries, namely low- and middle-income countries who continue to face issues accessing COVID-19 vaccines. The company said it would be more efficient for it to aim to produce more of the vaccines themselves to deliver to poorer…
 
In this episode, Ayesha talks about World Arthritis Day, which is on October 12 every year, with this year’s theme being raising awareness about early diagnosis. In addition to timely diagnosis, there may soon be a preventative vaccine for inflammatory arthritic conditions such as rheumatoid arthritis. Researchers at the University of Toledo have d…
 
In this episode, Ayesha talks about the CDC’s updated guidance according to which the COVID-19 vaccines can be administered at the same time as the flu shot and other vaccines. The new guidelines comes after the federal health agency says there is now substantial data around the COVID-19 vaccines to show that it is safe to be administered alongside…
 
In this episode, Ayesha talks about the FDA’s new interactive quiz as part of its Bad Ad outreach program that targets misleading pharmaceutical promotions. Although the Bad Ad program is primarily directed towards healthcare providers, the general public can also anonymously report dubious ads to the FDA’s Office of Prescription Drug Promotion (OP…
 
In this episode, Ayesha discusses the FDA’s pending decision on authorizing COVID-19 vaccine boosters for the general public. While an FDA vaccine advisory committee voted against boosters for individuals 16 years of age and older last week, the FDA is still working towards its final decision on the matter. At the same time, the advisory panel reco…
 
With RNA being the popular new “it” molecule in genetic research, Ayesha discusses Eli Lilly’s new partnership with biotech company ProQR to develop RNA-based therapeutics in this episode. The $1.5 billion deal will see Lilly leverage ProQR’s proprietary RNA editing platform to develop targets of interest. The team discusses how the success of the …
 
Knee replacements may soon be getting smarter with the world’s first smart knee implant. In this episode, Ayesha discusses a new personalized knee implant with integrated smart technology that recently received FDA clearance. Using sensors and cloud connectivity, it can help patients and practitioners monitor post-operative progress in real-time. T…
 
If 20 percent of the 250 million antibiotic prescriptions written globally each year are unnecessary, are there more drug-resistant superbugs in our future? In this episode, Sarah talks about the importance of paying attention to antimicrobial resistance (AMR) and how surveillance programs will be key to preventing the next pandemic. The team debat…
 
In this episode, Sarah presents three ways that Alzheimer’s trials will change now that Biogen’s Aduhelm (aducanumab) has been approved by the FDA. The team discusses whether placebo-controlled trials are still ethical and how ongoing dementia studies can manage patient attrition. Can trials pivot to allow patients to aducanumab as a background the…
 
In this episode, Ayesha discussed the US Food and Drug Administration’s (FDA) authorization of a third dose of the Pfizer and Moderna COVID-19 vaccines for immunocompromised individuals. These individuals would primarily include organ transplant recipients, as well as patients taking immunosuppressive drugs for conditions like cancer and HIV/AIDS. …
 
In this episode, Ayesha discussed a presentation at this year’s Alzheimer’s Association International Conference (AAIC) 2021 about the impacts of COVID-19 on cognitive health. The study, conducted at New York University Langone Health, found that in cognitively normal COVID-19 patients that experienced the neurological symptom of confusion due to t…
 
In this episode, Sarah talked about attending the Alzheimer’s Association International Conference (AAIC) 2021 virtually this year and discussed increasing diversity in Alzheimer’s clinical trials as an important topic that was part of the conference. Black and Hispanic people are more likely to be diagnosed with Alzheimer’s compared to Caucasians.…
 
In this episode, Ayesha discusses a set of recommendations for use of the new FDA-approved Alzheimer’s treatment Aduhelm (aducanumab) published by an expert panel, which was shared at the Alzheimer’s Association International Conference (AAIC) 2021 this week. Ayesha and the team talked about the controversial approval of the drug, with lingering qu…
 
In this episode, Ayesha talks about the misleading headlines that ensued after WHO chief scientist Dr. Soumya Swaminathan made comments in a press briefing about mixing and matching COVID-19 vaccines and how there is currently no data to support additional doses and boosters at this time. News agencies like Reuters were at the helm of the misleadin…
 
In this episode, Ayesha talks about Nestlé’s marketing of Seres Therapeutics’ oral microbiome drug for recurrent C. Difficile infection (CDI). CDIs are the leading cause of hospital-acquired infections in the US, with recurrence being a common problem. It typically develops after the use of antibiotics which can wipe out the gut’s healthy bacteria.…
 
In this episode, Ayesha talks about the launch of a digital marketing campaign for the first FDA-approved therapeutic video game to help treat ADHD. The video game, called EndeavorRx, is installed as an app on smart phones and tablets. It was developed by digital medicine company Akili Interactive. The game is available by prescription and is indic…
 
In this episode, Ayesha talks about a peripheral nerve stimulation system for chronic pain developed by biotech company NeuraLace that received 510(k) FDA clearance last week. The device uses electromagnetic induction technology to directly target nerves damaged from injuries like accidents, surgery and burns among others. The goal is to stimulate …
 
In this episode, Ayesha discusses the results of a recent study that show Amazon’s Halo app can accurately estimate body fat percentage with results comparable to traditional DXA testing. The app has built-in AI algorithms that analyze images taken from a user’s smartphone, which are used to build a 3D model of the body and generate an estimate of …
 
In this episode, Ayesha talks about a new digital fabric fiber developed by MIT researchers. The fiber contains temperature sensors and memory devices that can sense, record, analyze and store digital health data. The polymeric fiber was designed with hundreds of microscale digital chips embedded into it and can be sewn into fabrics using a needle.…
 
In this episode, Ayesha talks about new research from Australia showing that eating fruit could lower the risk of developing type 2 diabetes. Researchers at the Edith Cowan University’s (ECU) Institute for Nutrition Research in Perth, Australia found that consuming at least two servings of fruit a day was linked to an over one third lower odds of d…
 
In this episode, Ayesha talks about Google’s new AI-based dermatology tool designed to help people identify and research conditions of the skin, hair and nails. The tool involves downloading an app on your phone and using its camera to take images of the affected area(s). These images, along with information about things like symptoms and skin type…
 
In this episode, Ayesha talks about Clinical Trials Day 2021 and how the COVID-19 pandemic spurred changes in trial procedures and perceptions of clinical research. At the onset of the pandemic, many clinical trial sites had to be shut down, prompting trial sponsors and practitioners to move to remote, decentralized clinical trial models. Researche…
 
In this episode, Ayesha discusses the latest trends in pharma tv ad spending, including the top spenders last week. The pandemic has led to a rise in both TV watching and health awareness, which pharma companies took advantage of by increasing spending on TV commercials by about 17 percent overall. Last week, three of the top ten TV ads by expendit…
 
In this episode, Ayesha discusses a new tool that uses CRISPR to modulate gene expression without editing DNA sequences. Dubbed “CRISPRoff,” the technology targets the epigenome to silence genes involved in diseases, with applications in cancer, AML and other conditions with a heritable component. The team debates the ethical considerations around …
 
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