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Breakthroughs

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Breakthroughs

Northwestern University Feinberg School of M

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Northwestern University Feinberg School of Medicine is a research-intensive medical school that fosters powerful collaborations on a thriving academic medical campus. We are driven by our mission to transform the practice of medicine and profoundly impact human health beyond the individual patient. We believe better answers only come from discovery.
 
Welcome to So You Want to Transform Healthcare, a podcast series created by Health2047 Inc., the innovation subsidiary of the American Medical Association. At Health2047, our mission is to find, found and scale innovative startups that transform healthcare at the system level before the AMA’s 200th anniversary in 2047. Innovating with intention is our business. In this podcast series, our Managing Director of Medical Affairs, Dr. M. Christine Stock—Professor Emerita from Northwestern’s Feinb ...
 
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show series
 
Dr. Michael Rakotz, current Vice President of Health Outcomes at the American Medical Association, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. They speak about Dr. Rakotz's national quality improvement initiative aimed at improving blood pressure control and preventing cardiovascular disease.…
 
Music-based medical interventions can have remarkable therapeutic benefits for patients diagnosed with cognitive impairments such as Alzheimer’s disease, dementia and Aphasia. Cognitive Behavioral Neurologist Borna Bonakdarpour, MD, explains how he is using and studying these clinical interventions through the new Northwestern Music and Medicine Pr…
 
A novel gene therapy promoted transfusion independence in more than 90 percent of adult and pediatric patients with transfusion-dependent beta-thalassemia. Study co-author Jennifer Schneiderman, MD, discusses results, published in the New England Journal of Medicine.By Northwestern University
 
Yuri Goryunov, partner and technology leader in the healthcare practice at McKinsey and Company, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. McKinsey and Company is a trusted advisor and counselor to many of the world's most influential businesses and institutions. At McKinsey, Yuri helps payers, prov…
 
Man's best friend is helping scientists find new treatments for brain tumors. Amy Heimberger, MD, is a board-certified neurosurgeon with extensive training and experience in the field of immunology. She is part of a promising new study in canine glioblastoma that could lead to more effective human glioblastoma clinical trials.…
 
Sachin Patel, MD, PhD, is the new chair and Lizzie Gilman Professor of Psychiatry and Behavioral Sciences at Feinberg and psychiatrist-in-chief at Northwestern Memorial Hospital’s Norman and Ida Stone Institute of Psychiatry. In this episode, he talks about the current mental health crisis in this country, his research and vision for the department…
 
According to the CDC, more Americans died of gun-related injuries in 2020 than in any other year on record. Judith Moskowitz, a social psychologist and professor of Medical Social Sciences at Feinberg, talks about how her NIH-funded research and intervention programs will be used to address stress and burnout in Chicago’s front-line violence preven…
 
Dr. Mira Irons, President and CEO of the College of Physicians of Philadelphia, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Mira Irons has held numerous leadership roles in all levels of medical education and authored over 100 peer-reviewed publications. They speak about how the power of national …
 
Buzz Stewart, CEO and co-founder of Medcurio, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Buzz has been using healthcare data in real-time for more than two decades with healthcare organizations such as Geisinger Health System and Sutter Health. They discuss Buzz's journey of founding and selling seve…
 
Cardiovascular disease is the leading cause of pregnancy-related deaths in the U.S. and according to a new Northwestern Medicine study published in the journal Circulation, about sixty percent of women in the U.S. have poor heart health before becoming pregnant. Study authors Sadiya Khan, MD and Natalie Cameron, MD, explain the results of the study…
 
In response to the first successful animal heart transplant into a human patient, internationally renowned transplant surgeon Satish Nadig, MD, PhD, reviews some of the scientific developments that have culminated in this moment, and stresses the ongoing need for other experimental strategies. Dr. Nadig is also the new director of Feinberg's Compre…
 
Dr. Cheryl Rucker-Whitaker, founding CEO of Complete Care Management Partners, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Cheryl Rucker-Whitaker is an entrepreneur, a physician, and an expert in translating epidemiologic, acute care, and social determinants of health data to services that meet pa…
 
Since coming to Northwestern in 2013, Deborah Smith Clements, MD, chair of Family & Community Medicine, has established three thriving family medicine residency programs and has been an advocate for improving the residency match process, health policy and social justice. She talks about her work, leading her department through COVID-19 and her rece…
 
While 2021 was not all we hoped for, it certainly was a transformative time in US healthcare. Dr. M Christine Stock reflects on the frank discussions she's had with innovators over the past year. Hear from individual entrepreneurs working in technology innovation, philanthropy, and government to transform healthcare. Thank you to all of our guests …
 
Immunotherapy has revolutionized cancer treatment over the last few decades, though not for glioblastoma — the most common and deadly malignant brain tumor. However, Northwestern Medicine neurosurgeon Adam Sonabend, MD, shares promising research on the potential benefits of immunotherapy for certain glioblastoma patients.…
 
What do we know about the effectiveness of COVID-19 boosters, and how might they better protect us from new variants such as omicron? Alexis Demonbreun, PhD, assistant professor of Pharmacology, offers insight. She is the author of a new study that shows COVID-19 boosters seem to supercharge antibody response.…
 
Millions of molecular proteins are swimming through our body's cells and many studies have discovered that these proteins are the main drivers of all human diseases. Scientists are now mapping proteins the way the Human Genome Project mapped genes. Northwestern's Neil Kelleher is at the forefront of the Human Proteoform Project and explains how it …
 
Sam Glassenberg, founder and CEO of Level Ex, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Sam Glassenberg has been leading teams at the cutting edge of the video game industry. They discuss how Sam and his team at Level Ex harnesses video game technology and cognitive neuroscience to engage and train …
 
Regenerative nanomedicine is being used to develop new therapies for devastating conditions such as severe spinal cord injuries. Northwestern's Dr. Samuel Stupp is a pioneer in the field of regenerative nanomedicine and recently published a paper in the journal Science that details how a new injectable therapy uses synthetic nanofibers to reverse s…
 
Northwestern Medicine scientists have discovered one of the earliest signs of Parkinson's disease, proving that damaged neuronal mitochondria alone can cause symptoms of the disease, according to a study published in Nature. Senior author D. James Surmeier, chair of the Feinberg department of Neuroscience, who has over 30 years of experience in the…
 
People who are Black make up the largest group of minorities in need of an organ transplant. In 2019, Northwestern Medicine launched the African American Transplant Access Program to help address this problem. Founding director of the program Dinee Simpson, MD, talks about the barriers to organ transplant for Black patients and how she is working t…
 
Dr. Lee Fleisher, the CMS Chief Medical Officer and Director of the Center for Clinical Standards and Quality, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Lee Fleisher is also a Professor of Anesthesiology, Critical Care, and Medicine at the University of Pennsylvania Perelman School of Medicine. …
 
This spring, the World Health Organization began using the Greek alphabet to label key variants of SARS-CoV-2. The Greek names make it easier to talk about variants with the public, but in the scientific community these variants are being discussed and studied at the molecular level to learn as much as possible about their evolution, replication an…
 
While there are more treatments now than ever before for neuromuscular diseases like muscular dystrophy, patients who have very specific gene mutations associated with these diseases have few options. Dr. Elizabeth McNally says a discovery in her lab could lead to a new therapy for muscular dystrophy, including its rare forms.…
 
As the Delta variant of SARS-CoV-2 is causing breakthrough infections in some vaccinated people around the world, scientists at Northwestern Medicine are developing and studying potential next-generation COVID-19 vaccines that could be more effective at preventing and clearing breakthrough infections. Pablo Penaloza-MacMaster, assistant professor o…
 
As heart conditions like arrhythmia become increasingly common, heart monitoring is becoming an even more important tool for disease prevention and treatment. Northwestern Medicine cardiac electrophysiologist Rod Passman, MD, who has over three decades of experience in the field, reviews the history of cardiac monitoring and looks to the future. He…
 
Dr. Joe Kvedar, professor of Dermatology at Harvard Medical School and Senior Advisor for virtual care at Mass General Brigham, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Joe Kvedar is internationally recognized for his leadership and vision in the field of connected healthcare. They discuss inn…
 
Esophageal diseases are extremely common, and symptoms such as trouble swallowing, chest pain, regurgitation and choking diminish quality of life. There can also be psychosocial effects for patients with these diseases that includes hypervigilance — a heightened focus on physical symptoms — and symptom-specific anxiety such as fear of choking. Iden…
 
Dr. Eric E. Whitaker, founder and CEO of Zing Health, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Whitaker is a nationally recognized authority on public health and an expert in the health issues of African American communities. They discuss how Zing Health provides healthcare solutions for medic…
 
A recent survey of more than 32,000 caregivers of Chicago Public School students found that around a quarter children and adolescents were described as stressed, anxious, angry or agitated in the months after remote learning began. Black and Latinx participants experienced significantly more of these stressors. Dr. Tali Raviv, associate professor o…
 
Gerry Miller, founder and CEO of Cloudticity, a digital enablement partner empowering healthcare organizations to leverage the cloud, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. From managing electronic health records to executing the New York State Department of Health's COVID-19 pandemic response, …
 
Recently, the director of the CDC officially recommended that pregnant women receive the vaccines for COVID-19. However, pregnant women are less likely than non-pregnant women to get vaccinated and are at greater risk of hospitalization and death from the disease. Emily Miller, MD, MPH, has been caring for pregnant patients at Prentice Women's Hosp…
 
Dr. Jesse Ehrenfeld, Director of the Advancing a Healthier Wisconsin Endowment and Senior Associate Dean and professor at the Medical College of Wisconsin School of Medicine, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss how philanthropy can drive health innovation and the many projects th…
 
COVID-19 can be a multi-system disease, impacting many organs and the entire nervous system. Igor Koralnik, MD, has been investigating the neurologic symptoms of the disease and published the first study focused on long-term neurological symptoms in COVID-19 “long haulers.” He explains the study and what he is seeing in the Neuro COVID-19 Clinic at…
 
At the beginning of the pandemic, Daniel Batlle, MD, professor of medicine in the Division of Nephrology-Hypertension at Northwestern, proposed a hypothesis that soluble ACE2 could treat the SARS-CoV-2 virus and lead to full recovery and survival. Now, he has exciting preliminary results to share.By Northwestern University
 
Black men are more likely to get prostate cancer and more than twice as likely to die from the disease than other men. Dr. Edward Schaeffer has developed a research team to better understand this problem. In this show he talks about his latest discoveries, which are paving the way to precision medicine for aggressive prostate cancer. Dr. Schaeffer …
 
Charles Aunger, Managing Director for Technology at Health2047, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss the current state of cybersecurity in healthcare organizations, the complexity of defending against attacks and, ultimately, where organizations should look to take healthcare cybe…
 
An early clinical trial in individuals with the deadly brain cancer glioblastoma showed an experimental spherical nucleic acid drug developed by Northwestern University scientists was able to penetrate the blood-brain barrier and trigger the death of tumor cells. Lead investigator Priya Kumthekar, MD, explains the results of the study.…
 
COVID-19 vaccines are being doled out across the nation, almost exclusively to adults. Pfizer's vaccine has been authorized for ages 16 and up and Moderna's vaccine for 18 and up. So when might younger children be vaccinated for COVID-19? And what needs to happen before then? Northwestern's William Muller, MD, PhD, offers insight.…
 
Dr. James Madara and Lawrence Cohen speak with host Dr. M. Christine Stock, Managing Director of ​Medical ​Affairs at Health2047. Dr. James Madara is CEO of the American Medical Association (AMA) and Lawrence Cohen, PhD, is CEO of Health2047. In celebration of Health2047’s 5th anniversary, they discuss how Health2047 was founded as an innovation su…
 
Since SARS-CoV-2 was discovered in Illinois over a year ago, Northwestern scientists have been tracking the evolution of the disease in the Chicago area. Ramón Lorenzo-Redondo, PhD, research assistant professor of Medicine in the Division of Infectious Diseases, is part of the team leading this work. He talks about the team's research, the new COVI…
 
Chris Komelasky and Neile Grayson speak with host Dr. M. Christine Stock, Managing Director of ​Medical ​Affairs at Health2047. Chris Komelasky is an advisor to Health2047 and Neile Grayson is a Managing Director of Corporate Portfolio and Project Management at Health2047. They discuss the importance of clinical research, the empowering impacts res…
 
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