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Breakthroughs

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Breakthroughs

Northwestern University Feinberg School of M

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Northwestern University Feinberg School of Medicine is a research-intensive medical school that fosters powerful collaborations on a thriving academic medical campus. We are driven by our mission to transform the practice of medicine and profoundly impact human health beyond the individual patient. We believe better answers only come from discovery.
 
Welcome to So You Want to Transform Healthcare, a podcast series created by Health2047 Inc., the innovation subsidiary of the American Medical Association. At Health2047, our mission is to find, found and scale innovative startups that transform healthcare at the system level before the AMA’s 200th anniversary in 2047. Innovating with intention is our business. In this podcast series, our Managing Director of Medical Affairs, Dr. M. Christine Stock—Professor Emerita from Northwestern’s Feinb ...
 
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Since coming to Northwestern 2013, Deborah Smith Clements, MD, chair of the Department of Family & Community Medicine, has established three thriving family medicine residency programs and has been an advocate for improving the residency matching process, health policy and social justice. She talks about her work, leading her department through COV…
 
While 2021 was not all we hoped for, it certainly was a transformative time in US healthcare. Dr. M Christine Stock reflects on the frank discussions she's had with innovators over the past year. Hear from individual entrepreneurs working in technology innovation, philanthropy, and government to transform healthcare. Thank you to all of our guests …
 
Immunotherapy has revolutionized cancer treatment over the last few decades, though not for glioblastoma — the most common and deadly malignant brain tumor. However, Northwestern Medicine neurosurgeon Adam Sonabend, MD, shares promising research on the potential benefits of immunotherapy for certain glioblastoma patients.…
 
What do we know about the effectiveness of COVID-19 boosters, and how might they better protect us from new variants such as omicron? Alexis Demonbreun, PhD, assistant professor of Pharmacology, offers insight. She is the author of a new study that shows COVID-19 boosters seem to supercharge antibody response.…
 
Millions of molecular proteins are swimming through our body's cells and many studies have discovered that these proteins are the main drivers of all human diseases. Scientists are now mapping proteins the way the Human Genome Project mapped genes. Northwestern's Neil Kelleher is at the forefront of the Human Proteoform Project and explains how it …
 
Sam Glassenberg, founder and CEO of Level Ex, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Sam Glassenberg has been leading teams at the cutting edge of the video game industry. They discuss how Sam and his team at Level Ex harnesses video game technology and cognitive neuroscience to engage and train …
 
Regenerative nanomedicine is being used to develop new therapies for devastating conditions such as severe spinal cord injuries. Northwestern's Dr. Samuel Stupp is a pioneer in the field of regenerative nanomedicine and recently published a paper in the journal Science that details how a new injectable therapy uses synthetic nanofibers to reverse s…
 
Northwestern Medicine scientists have discovered one of the earliest signs of Parkinson's disease, proving that damaged neuronal mitochondria alone can cause symptoms of the disease, according to a study published in Nature. Senior author D. James Surmeier, chair of the Feinberg department of Neuroscience, who has over 30 years of experience in the…
 
People who are Black make up the largest group of minorities in need of an organ transplant. In 2019, Northwestern Medicine launched the African American Transplant Access Program to help address this problem. Founding director of the program Dinee Simpson, MD, talks about the barriers to organ transplant for Black patients and how she is working t…
 
Dr. Lee Fleisher, the CMS Chief Medical Officer and Director of the Center for Clinical Standards and Quality, speaks with host Dr. M Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Lee Fleisher is also a Professor of Anesthesiology, Critical Care, and Medicine at the University of Pennsylvania Perelman School of Medicine. …
 
This spring, the World Health Organization began using the Greek alphabet to label key variants of SARS-CoV-2. The Greek names make it easier to talk about variants with the public, but in the scientific community these variants are being discussed and studied at the molecular level to learn as much as possible about their evolution, replication an…
 
While there are more treatments now than ever before for neuromuscular diseases like muscular dystrophy, patients who have very specific gene mutations associated with these diseases have few options. Dr. Elizabeth McNally says a discovery in her lab could lead to a new therapy for muscular dystrophy, including its rare forms.…
 
As the Delta variant of SARS-CoV-2 is causing breakthrough infections in some vaccinated people around the world, scientists at Northwestern Medicine are developing and studying potential next-generation COVID-19 vaccines that could be more effective at preventing and clearing breakthrough infections. Pablo Penaloza-MacMaster, assistant professor o…
 
As heart conditions like arrhythmia become increasingly common, heart monitoring is becoming an even more important tool for disease prevention and treatment. Northwestern Medicine cardiac electrophysiologist Rod Passman, MD, who has over three decades of experience in the field, reviews the history of cardiac monitoring and looks to the future. He…
 
Dr. Joe Kvedar, professor of Dermatology at Harvard Medical School and Senior Advisor for virtual care at Mass General Brigham, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Joe Kvedar is internationally recognized for his leadership and vision in the field of connected healthcare. They discuss inn…
 
Esophageal diseases are extremely common, and symptoms such as trouble swallowing, chest pain, regurgitation and choking diminish quality of life. There can also be psychosocial effects for patients with these diseases that includes hypervigilance — a heightened focus on physical symptoms — and symptom-specific anxiety such as fear of choking. Iden…
 
Dr. Eric E. Whitaker, founder and CEO of Zing Health, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. Dr. Whitaker is a nationally recognized authority on public health and an expert in the health issues of African American communities. They discuss how Zing Health provides healthcare solutions for medic…
 
A recent survey of more than 32,000 caregivers of Chicago Public School students found that around a quarter children and adolescents were described as stressed, anxious, angry or agitated in the months after remote learning began. Black and Latinx participants experienced significantly more of these stressors. Dr. Tali Raviv, associate professor o…
 
Gerry Miller, founder and CEO of Cloudticity, a digital enablement partner empowering healthcare organizations to leverage the cloud, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. From managing electronic health records to executing the New York State Department of Health's COVID-19 pandemic response, …
 
Recently, the director of the CDC officially recommended that pregnant women receive the vaccines for COVID-19. However, pregnant women are less likely than non-pregnant women to get vaccinated and are at greater risk of hospitalization and death from the disease. Emily Miller, MD, MPH, has been caring for pregnant patients at Prentice Women's Hosp…
 
Dr. Jesse Ehrenfeld, Director of the Advancing a Healthier Wisconsin Endowment and Senior Associate Dean and professor at the Medical College of Wisconsin School of Medicine, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss how philanthropy can drive health innovation and the many projects th…
 
COVID-19 can be a multi-system disease, impacting many organs and the entire nervous system. Igor Koralnik, MD, has been investigating the neurologic symptoms of the disease and published the first study focused on long-term neurological symptoms in COVID-19 “long haulers.” He explains the study and what he is seeing in the Neuro COVID-19 Clinic at…
 
At the beginning of the pandemic, Daniel Batlle, MD, professor of medicine in the Division of Nephrology-Hypertension at Northwestern, proposed a hypothesis that soluble ACE2 could treat the SARS-CoV-2 virus and lead to full recovery and survival. Now, he has exciting preliminary results to share.By Northwestern University
 
Black men are more likely to get prostate cancer and more than twice as likely to die from the disease than other men. Dr. Edward Schaeffer has developed a research team to better understand this problem. In this show he talks about his latest discoveries, which are paving the way to precision medicine for aggressive prostate cancer. Dr. Schaeffer …
 
Charles Aunger, Managing Director for Technology at Health2047, speaks with host Dr. M. Christine Stock, Managing Director of Medical Affairs at Health2047. They discuss the current state of cybersecurity in healthcare organizations, the complexity of defending against attacks and, ultimately, where organizations should look to take healthcare cybe…
 
An early clinical trial in individuals with the deadly brain cancer glioblastoma showed an experimental spherical nucleic acid drug developed by Northwestern University scientists was able to penetrate the blood-brain barrier and trigger the death of tumor cells. Lead investigator Priya Kumthekar, MD, explains the results of the study.…
 
COVID-19 vaccines are being doled out across the nation, almost exclusively to adults. Pfizer's vaccine has been authorized for ages 16 and up and Moderna's vaccine for 18 and up. So when might younger children be vaccinated for COVID-19? And what needs to happen before then? Northwestern's William Muller, MD, PhD, offers insight.…
 
Dr. James Madara and Lawrence Cohen speak with host Dr. M. Christine Stock, Managing Director of ​Medical ​Affairs at Health2047. Dr. James Madara is CEO of the American Medical Association (AMA) and Lawrence Cohen, PhD, is CEO of Health2047. In celebration of Health2047’s 5th anniversary, they discuss how Health2047 was founded as an innovation su…
 
Since SARS-CoV-2 was discovered in Illinois over a year ago, Northwestern scientists have been tracking the evolution of the disease in the Chicago area. Ramón Lorenzo-Redondo, PhD, research assistant professor of Medicine in the Division of Infectious Diseases, is part of the team leading this work. He talks about the team's research, the new COVI…
 
Chris Komelasky and Neile Grayson speak with host Dr. M. Christine Stock, Managing Director of ​Medical ​Affairs at Health2047. Chris Komelasky is an advisor to Health2047 and Neile Grayson is a Managing Director of Corporate Portfolio and Project Management at Health2047. They discuss the importance of clinical research, the empowering impacts res…
 
In this episode, host Erin Spain takes a look and listen back on some of the top Feinberg research published in 2020. Hear how Northwestern scientists responded to COVID-19 while publishing high-impact papers unrelated to the pandemic and making vital discoveries across the research enterprise during a difficult time.…
 
Mark Bagnall, Executive in Residence at Health2047 and ​CEO of Phenomix Sciences, speaks with host Dr. M. Christine Stock, Managing Director of ​Medical ​Affairs at Health2047. They discuss Phenomix’s approach to obesity treatment and what entrepreneurs should know about the process of creating a startup company in the healthcare space.…
 
Daphne Li, Managing ​Director of ​Business ​Acceleration at Health2047 and ​Chief Operating ​Officer at First Mile Care, speaks with host Dr. M. Christine Stock, Managing Director of ​Medical ​Affairs at Health2047. They discuss First Mile Care for diabetes prevention and a new venture that will ease the financial and business-related burdens endur…
 
A $30 million dollar, phase 3 clinical trial is about to begin at Northwestern, investigating whether exercise can slow Parkinson's disease progression. Daniel Corcos, PhD, a professor of Physical Therapy and Human Movement Sciences is leading the trial and explains what he hopes to accomplish.By Northwestern University
 
A Swiss Amish community in Indiana has been the focus of ongoing studies led by Dr. Douglas Vaughan, chair of the Department of Medicine at Northwestern. Many members of this Amish community have a gene mutation that appears to protect against biological aging in a variety of ways. A new experimental drug that effectively lowers the level of the pr…
 
Although COVID-19 doesn't necessarily discriminate, some communities are far more susceptible to the disease. People who are black or African-American are more likely to contract the virus - and to die from it. Clyde Yancy, MD, discusses reasons for these outcomes and the need to fully address health care disparities in America.…
 
While the world anxiously awaits a vaccine for COVID-19, some physicians on the front lines are trying new or repurposed therapies in an effort to help COVID patients. Dr. Benjamin Singer, a Northwestern physician-scientist, discusses his experiences in the ICU during this time and his recently published letter warning against the use of unproven t…
 
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